Steroids. III. New Synthesis of Ring-D Seco Steroids
نویسندگان
چکیده
منابع مشابه
Synthesis of Novel 17-Oxo-17a-Aza-D-Homo-3, 5-Seco-Steroids as Potential 5α-Reductase Inhibitors
Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland. Itis a leading disorder of the elderly male population. Excessive production of dihydrotestosteronehas been implicated in this pathological condition. Steroidal 5α-reductase is a membrane boundNADPH dependent enzyme which is responsible for the conversion of testosterone (T) todihydrotestosterone (DHT). The...
متن کاملsynthesis of novel 17-oxo-17a-aza-d-homo-3, 5-seco-steroids as potential 5α-reductase inhibitors
benign prostatic hyperplasia (bph) is a non-malignant enlargement of the prostate gland. itis a leading disorder of the elderly male population. excessive production of dihydrotestosteronehas been implicated in this pathological condition. steroidal 5α-reductase is a membrane boundnadph dependent enzyme which is responsible for the conversion of testosterone (t) todihydrotestosterone (dht). the...
متن کاملStructure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.
Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New A,D-ring modified steroid analogues of formestane and testolactone were designed and synthesized and their biochemical activity was investigated in vitro in an attempt to find new aromatase inhibitors and to gain insight into their structure-activity relationships (SAR). All compounds tested ...
متن کاملRearrangement of 14/3-Hydroxy-12ß-sulfoxy-steroids to 13,17-Seco-12,17-cyclo-steroids; a 2D-NMR Analysis
During our work on cardiaoctive steroids we studied the elimination of the 12/3-sulfoxy-group. It is well known that 12/J-tosyloxyor 12/3-mesyloxysteroids with C/D-trans juncture undergo elimination to yield C-nor-D-homo steroids with 12(13) or 13(18) double bonds [1—6]. The same rearrangement product was obtained by the reaction of a 12/3-tosyloxycardenolide [7] with C/D-eis juncture. No GrobF...
متن کاملSeco-B-Ring Steroidal Dienynes with Aromatic D Ring: Design, Synthesis and Biological Evaluation
Continuing our structure-activity studies on the vitamin D analogs with the altered intercyclic seco-B-ring fragment, we designed compounds possessing dienyne system conjugated with the benzene D ring. Analysis of the literature data and the docking experiments seemed to indicate that the target compounds could mimic the ligands with a good affinity to the vitamin D receptor (VDR). Multi-step s...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1983
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.56.355